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  1. More Images

    Molecular Evolutionary Genetics Analysis

    Software for statistical analysis of molecular evolution
    megasoftware.net

    Molecular Evolutionary Genetics Analysis is computer software for conducting statistical analysis of molecular evolution and for constructing phylogenetic trees. It includes many sophisticated methods and tools for phylogenomics and phylomedicine. It is licensed as proprietary freeware. The project for developing this software was initiated by the leadership of Masatoshi Nei in his laboratory at the Pennsylvania State University in collaboration with his graduate student Sudhir Kumar and postdoctoral fellow Koichiro Tamura. Nei wrote a monograph outlining the scope of the software and presenting new statistical methods that were included in MEGA. The entire set of computer programs was written by Kumar and Tamura. The personal computers then lacked the ability to send the monograph and software electronically, so they were delivered by postal mail. From the start, MEGA was intended to be easy-to-use and include solid statistical methods only. Wikipedia

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  2. megasoftware.net

    MEGA 11: Molecular Evolutionary Genetics Analysis version 11. Version 11 adds new timing methods and is optimized for working with larger data. MEGA 11 introduces expanded relaxed-clock dating methods. Calibration densities, tip dating, and a rate auto-correlation test have been added to MEGA. ...
    • Features

      MEGA is an integrated tool for conducting automatic and manual sequence alignment, inferring phylogenetic trees, mining web-based databases, estimating rates of molecular evolution, and testing evolutionary hypotheses.

    • Instructional Videos

      Tutorials. Below are links to online video lectures and tutorials for multiple versions of MEGA. The first section of videos were created by members of Dr. Sudhir Kumar's lab at the Institute for Genomics and Evolutionary Medicine at Temple University.The rest of the videos were produced by users of MEGA.

    • documentation

      Help docs and user manuals for the MEGA genetics analysis software

    • feedback

      Report bugs or other issues regarding the MEGA software

    • walk through

      Phylogenetic analysis on two or more DNA or amino acid sequences requires that the sequences be aligned so that the substitutions can be accurately enumerated. ... A method for detecting correlation of evolutionary rates in a phylogenetic tree (Tao et al. 2018) ... NCBI is a federally funded resource for molecular biology information. NCBI ...

    • books / articles

      MEGA: Molecular Evolutionary Genetics Analysis version 1.01 . Kumar S, Tamura K, Nei M (1993) The Pennsylvania State University (135 pp.) Web Link Download PDF. Other Resources: MEGA Software Celebrates Silver Anniversary Caspermeyer J (2018) Molecular Biology and Evolution 35:1558-1560 ...

  3. en.wikipedia.org

    Molecular Evolutionary Genetics Analysis (MEGA) is computer software for conducting statistical analysis of molecular evolution and for constructing phylogenetic trees.It includes many sophisticated methods and tools for phylogenomics and phylomedicine.It is licensed as proprietary freeware.The project for developing this software was initiated by the leadership of Masatoshi Nei in his ...
  4. pubmed.ncbi.nlm.nih.gov

    The Molecular Evolutionary Genetics Analysis (MEGA) software has matured to contain a large collection of methods and tools of computational molecular evolution. Here, we describe new additions that make MEGA a more comprehensive tool for building timetrees of species, pathogens, and gene families using rapid relaxed-clock methods. ...
    Author:Koichiro Tamura, Glen Stecher, Daniel Peterson, Alan Filipski, Sudhir Kumar, Sudhir KumarPublished:2013
  5. academic.oup.com

    MEGA6 is a free software for comparing DNA and protein sequences and inferring molecular evolutionary patterns and divergence times. It implements the RelTime method for estimating relative times of divergence for all branching points in a phylogeny and provides a graphical user interface for timetree exploration.
  6. pubmed.ncbi.nlm.nih.gov

    We introduce the 12th version of the Molecular Evolutionary Genetics Analysis (MEGA) software. This latest version brings many significant improvements by reducing the computational time needed for selecting optimal substitution models and conducting bootstrap tests on phylogenies using maximum likelihood (ML) methods.
  7. academic.oup.com

    Dec 21, 2024MEGA12 is the latest version of the Molecular Evolutionary Genetics Analysis software, which offers various tools for phylogenetic analyses using ML, MP, Bayesian, and distance methods. It also includes heuristics to reduce computational time and carbon footprint, and links to an external application for detecting fragile clades and sequences.
  8. pmc.ncbi.nlm.nih.gov

    Molecular Evolutionary Genetics Analysis (M ega) software is now being applied to increasingly bigger datasets ( Kumar et al. 1994; Tamura et al. 2013).This necessitated technological advancement of the computation core and the user interface of M ega.Researchers also need to conduct high-throughput and scripted analyses on their operating system of choice, which requires that M ega be ...
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